Certified Diabetes Care and Education Specialist (CDCES) Practice Exam

Which of the following is NOT a potential side effect of niacin?

1. Flushing

2. Hepatotoxicity

3. Hyperuricemia

4. Hypoglycemia

The correct answer is: Hypoglycemia

The correct answer is that hypoglycemia is not a potential side effect of niacin. Niacin, also known as vitamin B3, is used to treat dyslipidemia and has various effects on lipid profiles, typically increasing HDL ("good" cholesterol) and decreasing triglycerides and LDL ("bad" cholesterol). Niacin is known for several side effects, including flushing, which is caused by the release of prostaglandins and often resolved by gradual dose escalation or taking aspirin beforehand. Hepatotoxicity is another serious potential side effect, especially at high doses used for treating dyslipidemia, as it can lead to liver damage. Additionally, hyperuricemia can occur with niacin use, as it can reduce renal excretion of uric acid, potentially leading to gout. In contrast, hypoglycemia is not associated with niacin use. While niacin can affect glucose metabolism, leading to insulin resistance in some individuals, it does not typically cause low blood sugar levels. Understanding these distinctions is crucial for diabetes management and patient education, as it informs healthcare providers about the safe use of niacin in patients, particularly those who may be at risk for hypoglycemia.